In which form is the vaccine that must be stored at specific cold temperatures?

The vaccine that must be stored at specific cold temperatures is typically a live attenuated intranasal vaccine. Live attenuated vaccines contain live pathogens that have been weakened so they cannot cause disease in healthy individuals. Because they contain live organisms, they are sensitive to temperature fluctuations; improper storage can lead to loss of potency and effectiveness.

Cold chain storage is critical for these vaccines, which often require strict temperature control to maintain the viability of the live virus or bacteria they contain. This helps ensure that the vaccine will elicit a strong and lasting immune response when administered.

Other forms of vaccines, such as inactivated injections or intramuscular injections, might have more flexibility regarding storage temperatures because they do not contain live organisms. However, they still require appropriate temperature ranges to maintain stability and potency. Thus, the requirement for specific cold storage temperatures is most critical for live attenuated vaccines, especially those administered intranasally.